Compared to children without CFLD, those with CFLD had significantly elevated mean values of liver stiffness, serum ALT, and APRI over the follow-up while FIB-4 was not altered: TE(noCFLD) = 4.5±0.16 kPa and TE(CFLD) = 8.2±1.6 kPa with p<0.001, ALT(CFnoLD) = 24.7±1.6 U/l and ALT(CFLD) = 39.2±4.7 U/l with p<0.003, APRI(CFnoLD) = 0.20±0.02 and APRI(CFLD) = 0.36±0.08 with p = 0.007. This evidence concerns the gene GPT and cystic fibrosis-related liver disease.