Regarding the correlations between the expressions of CXCL1 and CXCR2 and clinicopathologic features, our results demonstrated that CXCL1 expression in cancer cells was associated with tumor cell invasion (T2–T4), lymph node metastasis, lymphatic invasion, venous invasion, peritoneal cytology, peritoneal metastasis and CXCR2 expression in stromal cells. This evidence concerns the gene CXCR2 and cancer.