SPEF2 and pancreatitis: Interestingly, the positive associations that were observed between rs11556218 in IL16 and rs34708521 in SPEF2 and the higher risk of pancreatitis were also seen in DFCI cohort (OR = 6.7; 95% CI, 1.1-41.5; p = 0.05 in patients with mild and moderate pancreatitis and OR = 3.4; 95% CI, 1.1-10.5; p = 0.02, Figures 5b and 5c, respectively).