ASPG and allergic disease: The observed frequencies of the asparaginase-related toxicities ware comparable to those reported in the literature [2, 4, 5, 8]: 15.9% (48) patients developed allergies (with 40 of them having serious systemic reactions while the rest having mixed or local reactions); 5% (15) experienced pancreatitis (12 severe and 3 mild to moderate); and 3.3% (10) had thrombosis.