To the best of our knowledge, no studies have investigated potential associations between SNPs in BMP2 and BMP4 and the incidence of RP, and no studies have incorporated BMP SNPs into existing models based on MLD for predicting the risk of RP (grade ≥ 2 or 3) in patients after definitive radiotherapy for NSCLC. This evidence concerns the gene BMP4 and non-small cell lung carcinoma.