In conclusion, we found that SNPs in BMP2 (rs235768, rs1980499, and rs3178250) can predict grade ≥ 2 or 3 RP after definitive radiotherapy for NSCLC, and including these SNPs in an existing model predicting RP risk based on age, performance status, and MLD could improve the predictive power. This evidence concerns the gene BMP2 and non-small cell lung carcinoma.