Similarly, Tasdogan et al. reported that a loading dose of dexmedetomidine of one microg/kg over 10 minutes followed by a maintenance dose of 0.2–2.5 microg/kg/h decreased serum TNF-a, IL-1β, and IL-6 levels in patients with severe sepsis after abdominal surgery [11]. This evidence concerns the gene TNF and Sepsis.