TGFB1 and neoplasm: We also reported that the mutational status of p53 is an important determinant of TGFβ/SMAD3-mediated NOX4 regulation in breast and lung epithelial cells, showing that p53- WT is a suppressor of NOX4 induction whereas tumor-associated mutant forms of p53 enhance NOX4 expression and ROS generation [21].