As a result, EpCAM expression was identified as a significant predictor of the chemoresistance in ovarian cancer patients according to the univariate logistic regression analysis (OR, 5.40; 95% confidence interval [CI], 1.06–27.47; P = 0.042) and the multivariate Cox proportional hazards model (OR, 11.12; 95% CI, 1.66–74.41; P = 0.013). This evidence concerns the gene EPCAM and ovarian cancer.