In present longitudinal study, we mainly observed that 1) APOE ε4 carriers had significantly decreased concentration of Aβ1-42 and increased frontal PiB uptake value relative to ε2 carriers and controls; 2) APOE ε4 allele was associated with increasing frontal WMH volume and severity of BG PVR at baseline; moreover, significant progression of frontal WMH volume in APOE ε4 carriers relative to ε2 carriers and controls; 3), in ε4 carriers, both the baseline frontal WMH volume and progression of frontal WMH volume was related with cognitive decline. The gene discussed is APOE; the disease is Mental deterioration.