LOX, a secreted amine oxidase involved in collagen crosslinking, has been associated with invasion of cancer cells at the primary site42, 43 and also formation of pre-metastatic niches at distant sites.44 In Kras(G12D)-mediated oncogenesis, Lox has been reported to promote lung AC progression and invasion through excess collagen deposition and β1 integrin signaling.45 Inhibition of Lox enzymatic activity alleviates this effect. This evidence concerns the gene KRAS and cancer.