TRPM6 and type 2 diabetes mellitus: In a small case-control study examining interactions between magnesium intake and loci in TRPM6 (transient receptor potential cation channel, subfamily M, member 6) associated with T2DM, in older women carried out over 10 years, it reported that women who were carriers of 2 rare alleles from nonsynonymous SNPs in TRPM6 (rs3750425 and rs2274924) had nearly 5 times the odds of T2DM when their magnesium intake was less than 250 mg/d [216].