CDKN1A and type 2 diabetes mellitus: In a different study, dietary supplementation with 0.5% quercetin in the diet for 2 weeks in STZ-induced T2DM BALB/c mice decreased blood glucose and enhanced serum insulin concentrations by inhibiting expression of cyclin-dependent kinase inhibitor p21 (WAF1/Cip1) (Cdkn1a) associated with cell proliferation in the liver and pancreas [35].