In MDCS cohort other allelic variants of genes encoding transcription factors involved in the WNT signalling pathway with greater susceptibility to T2DM that is modified by the diet are ZBED3 rs4457053 G>A and NOTCH2 rs10923931 G>T in which fibre consumption protects against the susceptibility to T2DM with higher fibre consumption in the risk allele carriers (T) for the case of NOTCH2 and in individuals homozygous for the risk factor (GG) in the case of ZBED3 [205]. The gene discussed is NOTCH2; the disease is type 2 diabetes mellitus.