T2DM rats fed a high-fat diet (HFD) and administered low-dose STZ injection naringin, were shown to improve β-cell function, ameliorating hyperglycemia, hyperinsulinemia and IR by increasing PPAR-γ and heat shock proteins (HSP) expression in the livers of diabetic rats [31]. The gene discussed is PPARG; the disease is type 2 diabetes mellitus.