The antibody used to target Ber-H2-scFv-hpRNase was BerH2, a scFv cloned from anti-CD30 hybridoma, Ber-H2-scFv-hpRNase revealed CD30-specific anti-tumor activity in BALB/c mice following challenge with CD30-positive tumor cells [141]. The gene discussed is TNFRSF8; the disease is neoplasm.