GH/IGF‐I may also promote brain repair through the local induction and release of a number of neurotrophic factors such as vascular endothelial growth factor, epidermal growth factor, and brain‐derived neurotrophic factor.48 Other suggested mechanisms are directly through reduction of neuroinflammation or improvement in peripheral metabolic factors such as metabolic syndrome. The gene discussed is VEGFA; the disease is metabolic syndrome.