These patterns corroborate previous studies showing that the increased expression of pAKT and its downstream target p4EBP1 discriminate sensitive from adaptive/resistant melanoma cell lines, better than pERK1/2 expression levels 4, 6, and are also consistent with the established notion that overexpressed surface receptors like PDGFRB are involved in the mechanisms of adaptive resistance in melanoma 4, 5. The gene discussed is PDGFRB; the disease is melanoma.