In 2010, Moretti and colleagues used retroviral vectors to generate patient-specific hiPSCs from members of a family affected by the autosomal-dominant missense mutation R190Q in the KCNQ1 gene and differentiated the patient-derived cells into functional cardiomyocytes that recapitulated in vitro electrophysiological features of the LQT1 disease phenotype and the therapeutic approach of β-blockade [84]. The gene discussed is KCNQ1; the disease is long QT syndrome 1.