IL18 and heart disorder: On this note, Chien and colleagues recently constructed an iPSC-based disease model from patients carrying a GLA mutation (IVS4+919 G>A) responsible for Fabry disease [203] and demonstrated for the first time that Interleukin-18 (IL-18), a pro-hypertrophic inflammatory cytokine involved in several cardiac diseases, is involved in the pathogenesis of the disease [204].