Analysis performed without stratifying on sex (Fig. 3) yielded an elevated risk for any cancer for insulin glargine use relative to human insulin for 0.5 year (RR 1.12, 95% CI 1.03, 1.20) and a lower risk for 1–2 years (RR 0.90, 95% CI 0.83, 0.98), 6–7 years (RR 0.72, 95% CI 0.56, 0.91) and 7–8 years (RR 0.62, 95% CI 0.44, 0.86). Here, INS is linked to cancer.