INS and cancer: Other analyses yielded a lower risk for any cancer in men for 0.5–1, 2–3 and >6 years of insulin detemir use relative to that of human insulin (ESM Table 1), and an increased risk in men and women combined (RR 1.18, 95% CI 1.05, 1.33) for <0.5 years of insulin glargine use relative to that of insulin detemir (Fig. 3).