The aim of the study was to analyze the prevalence of unrecognized cases with positive diabetes-associated autoantibodies among patients initially diagnosed with T2D, to describe their metabolic features and characterize the alterations in high sensitivity C-reactive protein (hs-CRP), interleukin 6 (IL-6), and tumor necrosis factor alpha (TNFα) in comparison with participants having negative autoantibodies and patients already known to meet the criteria for LADA. Here, TNF is linked to type 2 diabetes mellitus.