TP53 and colorectal carcinoma: Extensive studies evidence that miRNAs can regulate all the major pathways in CRC; briefly, this includes their impact on β-catenin/Wnt signaling (miR-135a/b, miR-139, miR-145, miR-17-92), proliferation (let-7 family, miR-18a, miR-21, miR-126, miR-143, miR-200c), apoptosis (miR-34a, miR-133b, miR-195), cell cycle control (miR- 34a, miR-192, miR-215, miR-675), p53 signaling (miR-34b/c), differentiation (miR-141, miR-200c), and migration and invasion (miR-126, miR-143, miR-196a, miR-200a/b/c, miR-373, miR-520c) [34].