Because both ovariectomy in female rats and castration in male rats do not alter basal AGT expression levels in the kidneys of non-salt-loaded Dahl rats [18], we hypothesized that epigenetic repressors such as HDACs limit intrarenal AGT expression in females and could at least in part explain the sex disparities in hypertension and renoprotection. Here, AGT is linked to Hypertension.