HDAC1 and carcinoma: A very recent study has demonstrated that prostate (LNCAP) and breast (MDA-MB-231) carcinoma cells are more sensitive to T cell-mediated lysis in vitro after clinically relevant exposure to epigenetic therapy with either vorinostat or entinostat and that genetic or pharmacological inhibition studies identified HDAC1 as a key determinant to reverse carcinoma immune escape [119].