Promoter regions of genes such as FOXD3, FOXE1, FOXG1, ID4, SLIT2, BNC1, SALL1, RIPK4, HAND2, SOX9, SOX11, NR2F2, TAL1, SIM2, PAX9, and TBX2 were also found to be hypermethylated in sync with earlier reported results in CLL [16, 19, 25]. The gene discussed is RIPK4; the disease is B-cell chronic lymphocytic leukemia.