We focused on these five genes as they had previously been shown in the literature to be epigenetically influenced in CLL [NFATC1 [11]], or in other malignancies [BIK [34], SPRY2 [35], TBX2 [36, 37], TSHZ3 [38, 39]]. This evidence concerns the gene SPRY2 and B-cell chronic lymphocytic leukemia.