As expected, MEIS1, PMEPA1, SOX7, SPRY1, CDK6, TBX2 were significantly downregulated (p < 0.05) while SPRY2 (p = 0.016), VIPR1 (p = 0.04) and ID4 (p = 0.03) were significantly upregulated in CLL cells as compared to healthy B-cells. This evidence concerns the gene SPRY2 and B-cell chronic lymphocytic leukemia.