PAX9 is one of the nine members of "paired box” (PAX)-containing transcription factor family and its inhibition has been shown to induce apoptosis with increased cleavage of caspase-3 and PARP, increased expression of BAX and decreased expression of BCL-2 in oral squamous cell carcinoma [53]. The gene discussed is CASP3; the disease is oral cavity squamous cell carcinoma.