SPRY1 and B-cell chronic lymphocytic leukemia: In the present analysis, an inverse correlation between methylation and gene expression was observed for 209 genes in CLL including transcription factors (ID4, NFATC1, TBX2, TAL1, MEIS1), SPRY family members (SPRY1, SPRY2) and SOX family members (SOX4, SOX7).