Magnetic resonance imaging, bioluminescence imaging, and positron emission tomography experiments as well as direct analysis of tumor infiltration revealed rapid and specific accumulation of intravenously injected NK-92 carrying first- and second-generation ErbB2-specific or EpCAM-specific CARs in orthotopic breast and subcutaneous prostate carcinoma xenografts in rodents (55, 63, 64, 67, 73), while parental NK-92 cells showed no tumor homing and were mainly localized to spleen and liver (55). The gene discussed is EPCAM; the disease is neoplasm.