ERBB2 and breast carcinoma: In the first report proposing CAR-engineered NK-92 cells as a continuously expanding off-the-shelf cell therapeutic, we also applied a first-generation CAR consisting of an ErbB2-specific scFv antibody fused to CD3ζ through a CD8α hinge region, which resulted in high and specific cytotoxicity of the genetically modified cells toward ErbB2-expressing breast cancer cells and other targets of solid tumor origins (23).