Therefore, after combining all available data and derived more precise and comprehensive assessment, we have updated this system review and meta-analysis to find out the reliable associations of GSTP1 (Ile105Val), GSTM1 (null/present) and GSTT1 (null/present) variants with the efficacy and clinical outcomes of NSCLC patients treated with platinum-based chemotherapy. The gene discussed is GSTM1; the disease is non-small cell lung carcinoma.