Previous studies provide the evidences that genetic variants of genes involved in the detoxification and DNA repair pathways including GSTP1, GSTM1, GSTT1, ERCC1, XPD, XPG, XRCC1 may influence the anti-cancer efficacy of platinum-based chemotherapy14, 29, 38, 41–45. The gene discussed is ERCC5; the disease is cancer.