Our updated meta-analysis enrolled 29 publications including 5414 NSCLC patients harboring GSTP1 IIe105Val variant, 16 publications including 3008 NSCLC patients harboring GSTM1 null or present variant, 11 publications including 2356 NSCLC patients harboring GSTT1 null or present variant, which are several times more than the previous two meta-analyses. The gene discussed is GSTM1; the disease is non-small cell lung carcinoma.