Accordingly, HF/DDE had a clear aggravation of glycaemic metabolism (Fig. 3A), with a significant effect of p,p’-DDE increasing fasting blood glucose levels and impairing glycaemia control with a pronounced tendency of increased fasting insulin levels and HOMA index for insulin resistance, effects to some extent already observed in St/DDE and in accordance with studies linking p,p’-DDE exposure to insulin resistance and T2D8, 29, 40–42. This evidence concerns the gene INS and Insulin resistance.