This cytokine, is implicated in T2D through the activation of the inflammasome, and important part of our innate immune system that responds to danger signals that are sensed by intracellular NOD-like receptors (NLRs), such as NLRP3 inflammasome that after activation facilitates caspase-1-dependent processing of pro-IL-1β into its active form71. The gene discussed is CASP1; the disease is type 2 diabetes mellitus.