However, almost all symptoms of DN were not exacerbated in the STZ-treated DGKα−/− mice against our prediction, for example, urine volume (DGKα+/+: 45.6 μl/g, DGKα−/−: 34.1 μl/g) and CCr (DGKα+/+: 7.50 μl/min, DGKα−/−: 5.48 μl/min) suggesting that ease of injury by hyperglycaemia easily occurs in DGKα−/− mice compared with the DGKα+/+ mice. Here, DGKA is linked to liver dysplastic nodule.