In Supplementary Figure 8,, we show a representative genome browser displaying novel JIA variants co-segregating with four histone signals (H3K27ac, H3K27me3, H3K4me1, H3K4me3) annotated in ENCODE and Roadmap Epigenomics data derived from CD20+ B cells, CD4+ T cells, and CD14+ monocytes at the chromosome 6 MHC region. This evidence concerns the gene CD4 and juvenile idiopathic arthritis.