Furthermore, our studies also reveal that the combined treatment with ENb and TRAIL was not sufficient in inducing apoptosis in TRAIL and ENb unresponsive tumor cells, suggesting that ENb-TRAIL binding to EGFR and DR5 was not only suppressing EGFR pathway and initiating apoptotic pathways, but had additional functions enabling ENb-TRAIL to strongly induce apoptosis in different tumor cell types. The gene discussed is TNFRSF10B; the disease is neoplasm.