To understand the dynamics of EGFR and DR5 on tumor cells post ENb-TRAIL binding and subsequent activation of DR5, we engineered fusion constructs EGFR-YFP, DR4-CFP and DR5-CFP and co-expressed EGFR-YFP and DR5-CFP or DR4-CFP in 293T cells (Figs 3A,B and S5B). Here, EGFR is linked to neoplasm.