Although the early lethality of αKOγKO mice (regardless of receiving control or Gdf15 shRNA due to heart failure; Wang et al, 2015b) prevented us from keeping monitoring their body weight following this molecular reversal of liver GH inhibition, these results demonstrate that GDF15 is a bona fide heart‐derived hormone that regulates liver GH signaling. Here, GDF15 is linked to heart failure.