Last, to substantiate the clinical significance of our findings beyond animal models, we asked whether GDF15 potentially underlies clinical FTT associated with pediatric heart disease, which often features lower circulating IGF1 and IGFBP3 levels (Barton et al, 1996; Dinleyici et al, 2007; Surmeli‐Onay et al, 2011; Peng et al, 2013). This evidence concerns the gene IGF1 and heart disorder.