APOE and Alzheimer disease: However, patterns of tau binding correlate better with both healthy ageing and AD than amyloid-beta (Brier et al., 2016, Ossenkoppele et al., 2016), and there is greater uptake of tau in ApoE4 carriers (carriers of the gene most strongly associated with the risk of developing AD) than non-carriers (Ossenkoppele et al., 2016).