These cascades help to counteract various tumour evasion strategies such as reduced antigen processing and presentation, increased tumour-permissive cytokine profiles, establishment of an immunosuppressive microenvironment, cellular immune escape via regulatory T-cells or myeloid-derived suppressor cells (MDSCs), and induction of anergic T-cells either by an increase of co-inhibitory receptors (e.g. CTLA-4 or PD-1) or decreased co-stimulatory receptors [25, 26]. Here, PDCD1 is linked to neoplasm.