PDGFRB and telomere syndrome: Pazopanib, a TKI targeting VEGFR 1–3, PDGFRA, PDGFRB and KIT, was tested in advanced, pre-treated STS patients, and showed an improvement in PFS of 3 months compared to placebo [45]; a good performance status and a low or intermediate tumour grade were selected as favourable prognostic factors.