EMT plays important roles in cancer invasion and metastasis, involving Vimentin as a cytoskeletal regulator of migration of mesenchymal cells and cell-surface E/N-cadherin switch (the expression of E-cadherin is switched off and that of N-cadherin is switched on) mediated by key transcription factors such as Snail and Twist [8]. Here, CDH2 is linked to cancer.