AKT1 and cancer: More studies are necessary in the future to (a) assess the tumorigenic pathways of Vimentin through its interaction with 14-3-3 and Akt-phosphorylated Beclin 1, which could contribute to control tumorigenesis [34]; (b) understand the regulation of Vimentin through hypoxia-inducible factor-1 and its role in the extracellular space or cell surface during EMT, which could contribute to the invasiveness of cancer cells [35]; (c) understand how Vimentin assembly and expression are regulated, which would help to elucidate the effect of Vimentin expression on metastasis [10].