In addition, VEGF delivery through retrograde transport of a lentiviral vector injected into several muscles delays onset and prolongs the survival of SOD1G93A mice, an animal model of ALS [21], and its intracerebroventricular infusion preserves neuromuscular junction in the SOD1G93A rat model of ALS [22]. Here, VEGFA is linked to amyotrophic lateral sclerosis.