Schaap FG et al. demonstrated high levels of FGF19 expression in the liver of patients with extrahepatic cholestasis [17], and more recently, Wunsch E et al. showed that hepatic FGF19 expression was significantly increased in both non-cirrhotic (9-folds of normal) and cirrhotic (69-folds of normal) PBC patients [19]. The gene discussed is FGF19; the disease is extrahepatic cholestasis.