In contrast, serum FGF19 concentrations in patients with cirrhotic PBC were significantly higher as compared to either healthy volunteer subjects (1674.0 ± 480.1 vs. 255.9 ± 48.5 ng/ml; p < 0.05) or patients diagnosed with non-cirrhotic PBC (1674.0 ± 480.1 vs. 645.6 ± 187.9 ng/ml; p < 0.05) (Fig 1A). The gene discussed is FGF19; the disease is primary biliary cholangitis.