As shown in Fig 2, we observe a positive correlation between concentrations of CRP and FGF19 (r = 0.501, p = 0.0004) (Fig 2A) and a negative correlation between CRP and C4 levels (r = -0.580, p = 0.0003)(Fig 2B) in PBC patients. Here, C4A is linked to primary biliary cholangitis.