Infection of macrophages from STING deficient mice with C. trachomatis failed to induce interferon-β expression (Fig 7A) and exhibited reduced IL-1β secretion (Fig 7B), cell death (Fig 7C) and reduced IL-1β processing and caspase-11 expression (Fig 7D) but had equivalent responses to LPS/ATP stimulation. Here, STING1 is linked to infection.