CAV1 and steatosis: We observed that the CAV1-deficient livers of HFD-fed mice exhibited greater expression of SREBP1; moreover, enhanced SREBP1 expression in two different and independent CAV1-knockdown hepatocyte steatosis models synergistically supports the notion that the loss of CAV1 accelerates the accumulation of hepatic lipids by inducing SREBP1 transcriptional activity.