In addition, the serum levels of the CRP, IL-6, and TNF-α were significantly higher in the mice with colon cancer than in those without (CRP: 4.643±1.369 vs. 3.340±0.498 μg/ml, p<0.05; IL-6: 10.8±8.8 vs. 2.6±1.5 pg/ml, p<0.05; TNF-α: 0.48±0.15 vs. 0.28±0.06pg/ml, p<0.05), while the serum IL-1β did not change between the mice with and without cancer. Here, TNF is linked to malignant colon neoplasm.