Upon treatment of these CRC cells with rottlerin, MACC1 mRNA levels were reduced to 50% at a concentration of 5 μM in SW48 cells, 2.5 μM in DLD-1 cells, and 20 μM in SW620 cells as compared to the solvent-treated control (p < 0.001, Fig 2D, 2E and 2F). Here, MACC1 is linked to colorectal carcinoma.