MACC1 and colorectal carcinoma: HCT116-MACC1p-Luc CRC cells stably expressing the human MACC1 promoter-driven luciferase reporter gene (Fig 1A) were used to screen the ChemBioNet library of more than 30,000 compounds, which includes the Sigma Library of Pharmacologically Active Compounds (LOPAC), for identification of potential transcriptional MACC1 inhibitors [30].