Furthermore, we recently investigated gene expression in abdominal subcutaneous WAT of non-obese and obese women in relation to systemic in vivo insulin sensitivity assessed after two hours hyperinsulinemic-euglycemic clamp [10].Surprisingly, systemic insulin resistance had a limited impact on the transcriptional response to insulin infusion and the difference between the insulin resistant and sensitive groups was much smaller than the overall effect of obesity per se on gene expression in WAT. This evidence concerns the gene INS and obesity due to melanocortin 4 receptor deficiency.