ADAMTS1 and female infertility: It has been reported that ADAMTS-1-null mice showed female infertility and impaired follicular development.26, 27 Subsequently, Brown et al.37 demonstrated that ADAMTS1 was required for extracellular matrix (ECM) remodeling during ovarian follicular development and formation of lymphatic vessels.38 In accordance with this, Russell et al.39 showed that pro-ADMATS1 was localized to cytoplasmic secretory vesicles and the mature form of ADAMTS1 was accumulated in ECM.