In addition, E2F1 expression is positively associated with FP (free progression) (hazard ratio (HR)=2.02; 95% CI, 1.63–2.49; P<0.001) and overall survival (OS) (HR=1.91; 95% CI, 1.59−2.29; P<0.001) in GC, which was supported by Kaplan–Meier plotter analysis (www.kmplot.com), using microarray data from 876 GC patients18 (Figure 1f). The gene discussed is E2F1; the disease is gastric cancer.