E2F1 has pivotal roles in tumor progression by modulation of both coding and non-coding transcripts,8, 9 and was reported to act as oncogenes or tumor suppressors to modulate tumorigenesis depending on different cell context.8, 10, 11 Accumulating evidence revealed E2F1 exert important effect on GC progression; however, the biology functions remain argued.12, 13, 14. This evidence concerns the gene E2F1 and neoplasm.