TP53 and acute lymphoblastic leukemia: Small molecules such as cAMP and PGE2 have been shown to attenuate DNA damage-induced accumulation of p53 in BCP-ALL cells and inhibit apoptosis.23, 24 However, we did not find any inhibitory effect of the cAMP analog 8-CPT-cAMP, the adenylyl cyclase activator forskolin, or PGE2 on doxorubicin accumulation in LNCaP cells (data not shown).