Although clinical application of ULMW-HA itself for the treatment of surface CD44-high B-precursor ALL cases would not be realistic because of its required high concentration in serum and predictable adverse events, CD44-targeted approaches will possibly become a useful treatment strategy not only for B-precursor ALL, but also for surface CD44-high hematological and non-hematological tumors if specific small compound(s) or anti-CD44 monoclonal antibody capable of mimicking the action of ULMW-HA could be successfully explored. The gene discussed is CD44; the disease is acute lymphoblastic leukemia.