As shown in Figure 5e, viable leukemia cells became strongly positive for HMGB1 predominantly in the cytoplasm after ULMW-HA stimulation, suggesting that HMGB1 is actively translocated from the nucleus to the cytosol after ULMW-HA stimulation and is eventually secreted into the extracellular space. The gene discussed is HMGB1; the disease is leukemia.