Study showed that in response to oxidative stress, Brg1 interacts with Nrf2 to mediate HO-1 induction.22 To determine the role of Nrf2 and HO-1 in Brg1-mediated attenuation of HIR injury, we established an in vitro cell model by subjecting AML12 hepatocytes to hypoxia/reoxygenation (H/R), which closely mimicked the stimuli and the effects of in vivo HIR and could effectively enhance Brg1 expression with adenovirus infection and reduce Brg1 by gene silence. This evidence concerns the gene HMOX1 and adenoviridae infectious disease.