22 However, whether overexpression of Brg1 could enhance Nrf2-mediated HO-1 gene transcription in hepatocyte subjected to ischemia/hypoxia and subsequent reperfusion/reoxygenation in vivo or in vitro in the epigenetic machinery remained unknown, if so, overexpression of Brg1 maybe a potential therapy in liver diseases involving ischemia–reperfusion. This evidence concerns the gene SMARCA4 and liver disorder.