This makes Class I HDACs promising targets for antitumor therapeutics.6, 7, 8, 9, 10 As modifications in HDAC8 expression did not affect cancer cell proliferation27, 28 and expression of Class I HDACs in CCA has not yet been studied, we set out to determine the expression of Class I HDACs (especially HDACs 1, 2 and 3) in CCA tissue. The gene discussed is HDAC8; the disease is cholangiocarcinoma.