EZH2 as a crucial component of PRC2 has been reported in some studies, which were involved in the regulation of cyclin D1.20, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34 Moreover, AKT/GSK-3B/cyclin D1 axis was the classic pathway involved in modulation of cyclin D1 in cancer cell.35, 36 Furthermore, EZH2 and AKT could influence expression of each other indicating that they constituted a positive loop.21, 37, 38, 39 In addition, one-fifth of all human lncRNAs identified is physically associated with EZH2.18, 19 Here, gain and loss of UCA1 assay in GC cell has been performed. The gene discussed is UCA1; the disease is cancer.