Defection and imbalance of G1/S transition have been considered as an important factor to trigger the development of cancer, which partly could be attributable to abnormal upregulation of cyclin D1.32, 33 Taken together, UCA1 upregulates cyclin D1 to accelerate G1/S transition, which promoted the GC cell proliferation and cycle progression. The gene discussed is CCND1; the disease is cancer.