PKM and familial pancreatic carcinoma: PKM2 overexpression was shown to promote colon cancer cell migration and cell adhesion by regulating STAT3-associated signaling.9 In addition, downregulation of PKM2 by miR-let-7a inhibited migration in gastric cancer.32 However, elucidating the underlying mechanism of PKM2 in regulating pancreatic cancer metastasis requires further investigation.