Compared to cells with native PKM2 levels, cells with lentivirus-driven PKM2 silencing showed no difference in apoptotic induction (Figures 3h, i and Supplementary Figure S2h), indicating that the inhibition of pancreatic cancer cell growth by lentivirus-mediated silencing of PKM2 does not occur through apoptosis. Here, PKM is linked to pancreatic neoplasm.