Previously, we have reported that PEDF could bind to low-density lipoprotein receptor-related protein 6 (LRP6) and hinder the Wnt ligand-induced dimerization of LRP6 and Fz receptor, thus block the activation of canonical Wnt signaling in diabetic complications.19, 20 It is unknown whether PEDF could also block Wnt/β-catenin activation and further suppress EMT and metastasis in NPC. This evidence concerns the gene SERPINF1 and nasopharyngeal carcinoma.