We established CNE2-IR cell lines with A20 overexpression (OE), CEN2 cell lines with A20 knockdown (KD) and their respective control cell lines (Figure 3b), and observed that A20 OE significantly decreased cell proliferation and induced cell apoptosis, whereas A20 KD significantly increased cell proliferation and inhibited cell apoptosis (Figures 3c and d), phenocopying those seen in the miR-125b inhibitor and mimic-transfected NPC cells, respectively. Here, CETN2 is linked to nasopharyngeal carcinoma.