Although A20/NF-κB signaling axis seems to largely account for the phenotype of NPC cells induced by miR-125b, indeed a single miRNA can target multiple mRNAs to regulate gene expression.36 Therefore, there might be other molecules such as BAK1, PPP1CA, and p53,37, 38, 39, 40, 41 which are also targeted by miR-125b in NPC cells. This evidence concerns the gene PPP1CA and nasopharyngeal carcinoma.