Numerous studies have indicated that A20 is involved in the pathogenesis of various types of lymphoid malignancies,24, 25, 26, 27, 28 multiple myeloma29, 30 and non-small cell lung cancer31 duo to its genetic or epigenetic inactivation, leading to A20 downregulation, which functions as a tumor suppressor. Here, TNFAIP3 is linked to neoplasm.