Several studies have reported that miR-125b activates NF-κB pathway by targeting A20.20, 21, 22 Therefore, we hypothesize that miR-125b is dysregulated in NPC, and has a crucial role in the pathogenesis of NPC by targeting A20 and then regulating NF-κB signaling activity. This evidence concerns the gene NFKB1 and nasopharyngeal carcinoma.