Nuclear factor κB (NF-κB) is an important regulator of proliferation and apoptosis.8 Activation of NF-κB signaling pathway has a crucial role in the development and progression of NPC.9, 10, 11, 12 NF-κB comprises two subunits, commonly p50(NFκB1)/p65(RelA), which in its inactive state is held in the cytoplasm by the inhibitor of NF-κB (IκB). The gene discussed is RELA; the disease is nasopharyngeal carcinoma.