Activation of NF-κB signaling pathway has a crucial role in the development and progression of NPC,9, 10, 11, 12 and A20 is a negative regulator of NF-κB signaling pathway.15, 16, 17, 18, 19 Therefore, we investigated whether NF-κB mediates miR-125b/A20-regulating NPC cell proliferation and apoptosis. The gene discussed is TNFAIP3; the disease is nasopharyngeal carcinoma.