CD8A and infection: It markedly increases T-cell-mediated killing by upregulating MHC-I expression on target cells, and may promote target cell differentiation and death directly.12, 13 IFNγ skews the helper T-cell response towards a Th1 profile, but may be inhibitory in some infection models by suppressing IL-17 and reducing neutrophil chemotaxis.14, 15, 16 Studies enhancing the expression of IFNγ by CD8 T cells have shown improved anti-tumor responses in vivo in several mouse models.17, 18