PALB2 and hereditary clear cell renal cell carcinoma: Interestingly, we identified three truncating or frameshift alterations on FANCC, FLCN, and MSH6, three loss-of-function genes associated, respectively, to Fanconi anemia (like PALB2, BRCA1, and RAD51C reported in Table 1) [32], renal cell carcinoma [33], and Lynch syndrome [34], with no previous direct connections to breast cancer.