PIK3CA and cancer: These include SERPINF2, a member of the serpin family with a clear role in cancer cell survival [58], PARD6A, a member of the PAR family involved in cell cycle gatekeeping and interacting with major cancer pathways like MAPK and PI3K [59], and HIST2H2AB, part of the cluster 2 of histones whose parallel family in cluster 1 is highly mutated in many cancer types [60, 61].